<p>The invention relates to a biopsy device (11) integrating automated biopsy mechanism in one handheld housing in order to position automatically the biopsy mechanism with a high accuracy in a patient 's body for obtaining relevant tissue samples. One embodiment of the invention is that the biopsy mechanism is made of at least one longitudinal profiled élément such that axial movements and/or rotations around the main élément axis is generated directly or indirectly from at least one actuator.</p>