摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method of preparing a solid oral dosage form containing one or more pharmaceutically active ingredients solubilized or suspended in a pharmaceutically acceptable solvent or liquid phase and encapsulated in seamless controlled release microcapsules. <P>SOLUTION: The pharmaceutically acceptable solvent or liquid phase may range from aqueous phase, organic solvent(s), glycols, oils and derivatives including mono-, di- and tri-glycerides of short, medium and long chain fatty acids. The microcapsules have a diameter of <1 to 8 mm and a drug loading of up to 90%. Additionally, the microcapsules may be coated to release the pharmaceutically active ingredient at specific sites and predetermined rates. <P>COPYRIGHT: (C)2011,JPO&INPIT |