| 发明名称 |
Polymeric prodrug with a self-immolative linker |
| 摘要 |
A cascade carrier linked prodrug is described which comprises a biologically active moiety and - a masking group having at least one nucleophile and being distinct from the carrier. In one preferred embodiment of the invention, the prodrug has the structure represented by formula (I). |
| 申请公布号 |
AU2010212335(B2) |
申请公布日期 |
2011.06.23 |
| 申请号 |
AU20100212335 |
申请日期 |
2010.08.13 |
| 申请人 |
ASCENDIS PHARMA A/S |
发明人 |
HERSEL, ULRICH;RAU, HARALD;SCHNEPF, ROBERT;VETTER, DIRK;WEGGE, THOMAS |
| 分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
| 代理机构 |
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代理人 |
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| 主权项 |
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