发明名称 |
Treatment of pain and other alpha 2 adrenergic-mediated conditions |
摘要 |
<p>The present invention provides the following components a) and b) for use in the treatment or prevention of pain in a mammal by co-administration of the components:
a) a first component comprising a compound whose activity results in direct or indirect stimulation of alpha 2 adrenergic receptor activity, and
b) a second component comprising an alpha 1 adrenergic receptor antagonist;
wherein the dosage of the first component necessary to provide a given level of analgesia is less than that for a similarly affected mammal administered with the first component as the sole analgesic agent, or wherein the amount of sedation caused by the administration of a dose of the first component effective to cause half maximal analgesia is less than that caused in a similarly affected mammal administered with the first component in a dose effective to cause half maximal analgesia in the absence of the second component.</p> |
申请公布号 |
EP2335734(A2) |
申请公布日期 |
2011.06.22 |
申请号 |
EP20110157644 |
申请日期 |
2004.08.19 |
申请人 |
ALLERGAN, INC. |
发明人 |
DONELLO, JOHN E.;GIL, DANIEL W. |
分类号 |
A61K45/06;A61K31/135;A61K31/137;A61K31/4168;A61K31/498;A61K31/506;A61K31/517;A61P29/00 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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