发明名称 |
METHODS RELATED TO IMMUNOSTIMULATORY NUCLEIC ACID-INDUCED INTERFERON |
摘要 |
Methods and compositions are provided for extending the clinical utility of IFN-.alpha. in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-.alpha. treatment and reduce IFN-.alpha. treatment-related side effects. In addition, methods are provides for supporting the survival and for activating natural interferon producing cells (IPCs)in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.
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申请公布号 |
CA2386019(C) |
申请公布日期 |
2011.06.21 |
申请号 |
CA20002386019 |
申请日期 |
2000.09.27 |
申请人 |
COLEY PHARMACEUTICAL GROUP, INC.;UNIVERSITY OF IOWA RESEARCH FOUNDATION;COLEY PHARMACEUTICAL GMBH |
发明人 |
HARTMANN, GUNTHER;BRATZLER, ROBERT L.;KRIEG, ARTHUR |
分类号 |
C07H21/04;A61K31/7088;A61K31/7125;A61K35/12;A61K38/00;A61K38/19;A61K38/21;A61K39/00;A61P1/00;A61P1/08;A61P1/16;A61P29/00;A61P31/12;A61P31/18;A61P31/22;A61P35/00;A61P35/02;A61P37/04;A61P43/00;C12N5/078;C12N5/0784;C12N15/117 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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地址 |
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