AGENT FOR PROPHYLAXIS AND TREATMENT OF ASTHENOPIA OR PSEUDOMYOPIA

摘要

Disclosed is a pharmaceutical composition for the prophylaxis and treatment of asthenopia or pseudomyopia, which comprises a compound having a Rho kinase inhibitory activity and a pharmaceutically acceptable carrier. The compound having the Rho kinase inhibitory activity, for example, has the following formula (I): (see formula I) wherein Ra is a group of the following formula (a), (b) or (c) : (see formula (a)) (see formula (b)) (see formula (c)) in which R is hydrogen, alkyl, phenyl or the like; R1 is hydrogen, alkyl, phenyl or the like; R2 is hydrogen or alkyl; R3 and R4 are hydrogen, alkyl or the like; A is a bond or alkylene; L is hydrogen, alkyl or the like; R5 is hydrogen, hydroxyl or the like; R b is hydrogen, alkyl or the like; and R c is optionally substituted heterocycle containing nitrogen.