发明名称 |
MICE THAT MAKE HEAVY CHAIN ANTIBODIES |
摘要 |
<p>Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion in an immunoglobulin constant region CH1 gene (optionally a deletion in a hinge region) of an IgG, IgA, IgD, and/or IgE, and wherein the mouse is capable of expressing a functional IgM. Genetically modified mice are described, including mice having a functional IgM gene and modified to have a deletion of a CH 1 domain and a hinge region in a heavy chain constant domain that is not an IgM, e.g., in an IgG heavy chain constant domain. Genetically modified mice that make human variable/mouse constant chimeric heavy chain antibodies (antibodies that lack a light chain), fully mouse heavy chain antibodies, or fully human heavy chain antibodies are provided.</p> |
申请公布号 |
WO2011072204(A1) |
申请公布日期 |
2011.06.16 |
申请号 |
WO2010US59845 |
申请日期 |
2010.12.10 |
申请人 |
REGENERON PHARMACEUTICALS, INC.;MACDONALD, LYNN;STEVENS, SEAN;MURPHY, ANDREW, J. |
发明人 |
MACDONALD, LYNN;STEVENS, SEAN;MURPHY, ANDREW, J. |
分类号 |
A01K67/027;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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