PI3K/AKT PATHWAY SUBGROUPS IN CANCER: METHODS OF USING BIOMARKERS FOR DIAGNOSIS AND THERAPY

摘要

The present invention relates to methods of dividing cancer into subgroups based upon Akt pathway gene expression. In one embodiment, the present invention provides a method of diagnosing glioblastoma multiforme (GBM) subtype in an individual by determining the presence of an abnormal expression of an Akt pathway gene cluster and diagnosing the cancer subtype in the individual.