发明名称 |
Preparation of micro-porous crystals and conjugates thereof |
摘要 |
A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.
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申请公布号 |
US7960124(B2) |
申请公布日期 |
2011.06.14 |
申请号 |
US20070824416 |
申请日期 |
2007.06.29 |
申请人 |
ROCHE DIAGNOSTICS OPERATIONS, INC.;UNIVERSITAET BERN |
发明人 |
POPOVIC ZORAN;TSOTSALAS MANUEL MATTHIAS;BUSBY MICHAEL;DE COLA LUISA;CALZAFERRI GION;JOSEL HANS-PETER |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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