发明名称 |
Therapeutic uses of monoclonal antibodies to the angiotensin-II type-1 receptor |
摘要 |
The use of monoclonal antibodies to the angiotensin-II type-I receptor is provided for the treatment of cancer and vascular smooth muscle cell proliferation. Specifically, use is provided of a monoclonal antibody or a fragment thereof to a peptide comprising the N-terminal portion of the angiotensin-II type-1 receptor defined by the sequence MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFG in the preparation of a medicament for the treatment of cancer or in the preparation of a medicament for the treatment of vascular smooth muscle (VSM) cell proliferation.
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申请公布号 |
US7951904(B2) |
申请公布日期 |
2011.05.31 |
申请号 |
US20030525277 |
申请日期 |
2003.08.21 |
申请人 |
QUEEN MARY & WESTFIELD COLLEGE |
发明人 |
BARKER STEWART;PUDDEFOOT JOHN RICHARD;VINSON GAVIN PAUL |
分类号 |
C07K5/00;A61K39/00;A61K39/395;A61K47/48;C07K7/06;C07K16/28 |
主分类号 |
C07K5/00 |
代理机构 |
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代理人 |
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地址 |
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