| 摘要 |
<p>Disclosed is a compound useful as an active ingredient for a pharmaceutical composition for treating FAAH-related diseases. Extensive studies have been made on compounds having an FAAH-inhibiting activity, and it is confirmed that a piperazine-1-carboxylate compound having a benzimidazol-2-ylcarbonyl, a benzofuran-2-ylcarbonyl or the like bound to position-4 in the piperazine moiety has an excellent FAAH-inhibiting activity and has an activity to increase the effective bladder capacity, an activity to ameliorate sleep disorder, an anti-diuretic activity and an analgesic activity on lower urinary tract pain including bladder pain. The carbamate compound has an excellent FAAH-inhibiting activity and can be used as a prophylactic and/or therapeutic agent for FAAH-related diseases, particularly nycturia, interstitial cystitis, painful bladder syndrome or chronic non-bacterial prostatitis/chronic pelvic pain syndrome.</p> |
