HETEROCYCLIC GAMMA SECRETASE MODULATORS.

摘要

The invention relates to the use of compounds of formula wherein R¹ is a five or six membered heteroaryl group, optionally substituted by one or two R'; R' is lower alkyl; R² is hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or cyano; Z is N, C, O or S; V is N, C(R''), O or S; W is N, C(R''), O, or S; Y is N or C; with the proviso that only one of Z, V or W may be O or S; R'' is hydrogen, lower alkyl, lower alkyl substituted by halogen or hydroxy, or is C(O)O-R⁴; L is a bond, -(CR⁴ 2)n-, -C(O)NR⁴-, -C(O)NR⁴CH2-, or -C(O)-; R⁴ may be the same or different and is hydrogen or lower alkyl; R³ is lower alkyl, phenyl, optionally substituted by one or more R''' or is cycloalkyl; R''' is halogen, cyano, lower alkyl, lower alkyl substituted by halogen or hydroxy, or is lower alkoxy or is C(O)O-R⁴; n is 1, 2 or 3; or to pharmaceutically active acid addition salts for the manufacture of medicaments for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.