COMPOSITION CONTAINING HOMOISOFLAVANONE AS ACTIVE INGREDIENT FOR PREVENTING AND TREATING OBESITY OR METABOLIC SYNDROME

摘要

The present invention relates to a composition for preventing and treating obesity, obesity-related complications or metabolic syndrome, containing homoisoflavanone or a pharmaceutically acceptable salt thereof as an active ingredient. More specifically, the present invention relates to: a pharmaceutical composition for preventing and treating obesity, obesity-related complications or metabolic syndrome by inhibiting differentiation of adipocytes and maintaining a high level of SIRT1, thereby reducing bodyweight, abdominal fat and glucose tolerance; a method for preventing and treating same comprising the step of administering to a subject in need thereof an effective amount of homoisoflavanone or a pharmaceutically acceptable salt thereof; and uses of homoisoflavanone or a pharmaceutically acceptable salt thereof for the preparation of a therapeutic agent. The composition of the present invention inhibits differentiation of adipocytes and maintains a high level of SIRT1, thereby reducing bodyweight, abdominal fat and glucose tolerance, and can thus be useful for the prevention and treatment of obesity, obesity-related complications or metabolic syndrome.