发明名称 |
Modified Blood Clotting Factors And Methods Of Use |
摘要 |
The invention provides compositions including modified blood clotting factors that have a non-native proteolytic cleavage site engineered into them allowing intracellular cleavage and secretion of an active form. The compositions are useful in the methods for treating a bleeding or clotting disorder.
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申请公布号 |
US2011126303(A1) |
申请公布日期 |
2011.05.26 |
申请号 |
US20100794215 |
申请日期 |
2010.06.04 |
申请人 |
THE CHILDREN'S HOSPITAL OF PHILADELPHIA |
发明人 |
HIGH KATHERINE A.;MARGARITIS PARIS;CAMIRE RODNEY |
分类号 |
A01K67/027;A61K31/7088;A61K38/00;A61K48/00;A61P7/04;C07H21/00;C07K14/745;C07K14/755;C12N5/10;C12N9/64;C12N15/63 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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