发明名称 |
AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE |
摘要 |
<p>The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B1, B2, B3, L, R1, R4, ring Z, m and p of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.</p> |
申请公布号 |
WO2011063272(A1) |
申请公布日期 |
2011.05.26 |
申请号 |
WO2010US57488 |
申请日期 |
2010.11.19 |
申请人 |
AMGEN INC.;PARAS, NICK A,;CHENG, YUAN;POWERS, TIMOTHY;BROWN, JAMES;HITCHCOCK, STEPHEN;JUDD, TED;LOPEZ, PATRICIA;XUE, QIUFEN;YANG, BRYANT |
发明人 |
PARAS, NICK A,;CHENG, YUAN;POWERS, TIMOTHY;BROWN, JAMES;HITCHCOCK, STEPHEN;JUDD, TED;LOPEZ, PATRICIA;XUE, QIUFEN;YANG, BRYANT |
分类号 |
C07D401/06;A61K31/4709;A61P25/28;C07D401/12;C07D401/14 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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