Modified carbocyanine dyes and their conjugates

摘要

Chemically reactive carbocyanine dyes and incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, as described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivate compounds having one or more benzo nitrogens.