发明名称 |
Three-Dimensional Structure Of The Amyloid Precursor Protein Intracellular Domain (AICD) In Complex With Human FE65-PTB2 |
摘要 |
The present invention relates to a three-dimensional structure of the intracellular domain (AICD) of human amyloid precursor protein (APP695) in complex with human Fe65-PTB2 (i.e. a protein-complex comprising the intracellular domain (AICD) of human amyloid precursor protein (APP695) and the human Fe65-PTB2), as well as to methods and uses of said three-dimensional structure for identifying ligands which modify the interaction between the AICD and the Fe65-PTB2. Moreover, the present invention relates to pharmaceutical compositions which contain one or more of such identified ligands for the prevention or treatment of neurodegenerative disorders.
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申请公布号 |
US2011118439(A1) |
申请公布日期 |
2011.05.19 |
申请号 |
US20090864563 |
申请日期 |
2009.01.29 |
申请人 |
UNIVERSITAT HEIDELBERG |
发明人 |
WILD KLEMENS;RADZIMANOWSKI JENS;SINNING IRMGARD;BEYREUTHER KONRAD |
分类号 |
C07K14/47;C07K19/00;G06G7/48 |
主分类号 |
C07K14/47 |
代理机构 |
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地址 |
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