PHARMACEUTICAL FORMULATIONS WITH LOW AQUEOUS LEVELS OF FREE UNBOUND DRUG

摘要

The complexation properties of cyclodextrins are combined with the partitioning properties of reversed lyotropic liquid crystalline phase microparticles to prepare pharmaceutical formulation dispersions with reduced levels of free unbound aqueous drug. Safe to inject formulations including, for example, propofol, include dispersions of reversed lyotropic liquid crystalline phase microparticles with propofol in an aqueous carrier together with cyclodextrins.