发明名称 |
METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES |
摘要 |
Provided is a method for preparing (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives of Formula (I) which are useful as blood coagulation factor Xa inhibitors, and said method using 1-fluoro-4-nitrobenzen as a starting material. According to the method of the present invention, (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives of Formula (I) which are useful as blood coagulation factor Xa inhibitors can be prepared in a high purity and a high yield. |
申请公布号 |
WO2011005028(A3) |
申请公布日期 |
2011.05.19 |
申请号 |
WO2010KR04420 |
申请日期 |
2010.07.07 |
申请人 |
LEGOCHEM BIOSCIENCE LTD.;CHO, YOUNG LAG;CHO, JONG UN;BAEK, SUNG YOON;SONG, HO YOUNG;PARK, TAE KYO;WOO, SUNG HO;KIM, YONG ZU |
发明人 |
CHO, YOUNG LAG;CHO, JONG UN;BAEK, SUNG YOON;SONG, HO YOUNG;PARK, TAE KYO;WOO, SUNG HO;KIM, YONG ZU |
分类号 |
C07D419/14;C07D419/08;C07D419/10 |
主分类号 |
C07D419/14 |
代理机构 |
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