SOLUTION ASSAY AND HIGH THROUGH-PUT SCREEN TO PROBE INTERACTION BETWEEN HUMAN CULLIN-RING LIGASE COMPLEX AND HIV-VIF PROTEIN

摘要

Methods for large-scale coexpresion and isolation of ElonginB, ElonginC, Vif are presented An assay for screening any agent that inhibits the ability of Vif to bind with CullinS is also presented An agent identified by the screening methods and methods of treatment using the identified agent are included.