T cell receptor fusions and conjugates and methods of use thereof

摘要

Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured are methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.