发明名称 |
METHOD FOR PREPARING DERIVATIVES OF FARNESYLACETONE AS ANTIHYPERTENSIVE AGENT AND ITS INTERMEDIATES |
摘要 |
PURPOSE: A method for preparing farnesylactone derivatives and an intermediate of the derivative are provided to effectively perform organic synthesis of 6,10,14-trimethylpentadeca-5,10-diene-2,12-dione. CONSTITUTION: A method for preparing farnesylactone compound comprises: a step of reacting a compound of chemical formula 4 with ethylene glycol and p-toluene sulfonic acid to prepare a compound of chemical formula 5; a step of reacting the compound of chemical formula 5 with sodium methoxide to obtain a compound of chemical formula 6; a step of reacting the compound of chemical formula 6 with diisobutyl aluminum hydride to obtain a compound of chemical formula 7; a step of reacting the compound of chemical formula 7 with isobutyl magnesium bromide to obtain a compound of chemical formula 8; a step of reacting the compound of chemical formula 8 with pyridinium chloro chromate to obtain a compound of chemical formula 9; and a step of reacting the compound of chemical formula 9 with pyridium p-toluenesulfonate. |
申请公布号 |
KR20110052109(A) |
申请公布日期 |
2011.05.18 |
申请号 |
KR20090109022 |
申请日期 |
2009.11.12 |
申请人 |
KWANDONG UNIVERSITY INDUSTRY FOUNDATION |
发明人 |
PARK, GAB MAN;PARK, BYONG GON;SHIN, WOON SEOB;LEE, SEOK JOON;OH, SANG TAE |
分类号 |
C07D317/10;A61K31/40;A61K31/4196;A61P9/12 |
主分类号 |
C07D317/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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