STEM CELL EXTRACTS AND USES THEREOF FOR IMMUNE MODULATION

摘要

Compositions and methods are described for modulating a subject's immune response and inducing immune tolerance. The composition comprises extracts of stem cells, for example, but not limited to human embryonic stem cells (hESCs), prepared by culturing the stem cells in a feeder-free cell culture system, collecting the stem cells, transferring the cells to a cell lysis buffer, lysing the stem cells in the cell lysis buffer to produce a lysate, and fractionating the lysate into soluble and insoluble fractions wherein the stem cell extract comprises the soluble or insoluble fraction. The extracts can be used to treat and/or prevent a variety of medical conditions, for example, but not limited to treating autoimmune diseases such as Graft Versus Host Disease (GVHD) or rheumatoid arthritis (RA), or to prevent transplant rejection.