发明名称 |
Motif-grafted hybrid polypeptides and uses thereof |
摘要 |
Provided herein are hybrid polypeptides that specifically bind to a disease-associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment, a hybrid protein that specifically binds to the infectious form of a prion (PrPSc) is provided.
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申请公布号 |
US7939641(B2) |
申请公布日期 |
2011.05.10 |
申请号 |
US20030410907 |
申请日期 |
2003.04.08 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
BURTON DENNIS R.;MORONCINI GIANLUCA;WILLIAMSON R. ANTHONY |
分类号 |
C07K16/00;G01N33/53;A61K39/395;A61K39/42;C07K14/47;C07K16/10;C07K16/18;C07K16/42;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/62;C12P21/08;C12Q1/02;G01N33/68 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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