发明名称 |
Proteolytically cleavable fusion proteins with high molar specific activity |
摘要 |
The invention relates to therapeutic fusion proteins in which a coagulation factor is fused to a half-life enhancing polypeptide, and in which both are connected by a linker peptide that is proteolytically cleavable. The cleavage of such linkers liberates the coagulation factor from activity-compromising steric hindrance caused by the half-life enhancing polypeptide and thereby allows the generation of fusion proteins may show relatively high molar specific activity when tested in coagulation-related assays. Furthermore, the fact that the linker is cleavable can enhance the rates of inactivation and/or elimination after proteolytic cleavage of the peptide linker compared to the rates measured for corresponding therapeutic fusion proteins linked by the non-cleavable linker having the amino acid sequence GGGGGGV.
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申请公布号 |
US7939632(B2) |
申请公布日期 |
2011.05.10 |
申请号 |
US20070000739 |
申请日期 |
2007.12.17 |
申请人 |
CSL BEHRING GMBH |
发明人 |
METZNER HUBERT;WEIMER THOMAS;SCHULTE STEFAN |
分类号 |
A61K38/36;A61K38/38;A61K38/48;C07K14/76 |
主分类号 |
A61K38/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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