发明名称 |
THYMIDYLATE KINASE FUSIONS AND USES THEREOF |
摘要 |
The application relates to a composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) wherein the modified mammalian tmpk increases phosphorylation of a prodrug relative to phosophorylation of the prodrug by wild-type human tmpk; and a detection cassette fused to tmpk. The application also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer. |
申请公布号 |
US2011104130(A1) |
申请公布日期 |
2011.05.05 |
申请号 |
US20090933460 |
申请日期 |
2009.03.20 |
申请人 |
UNIVERSITY HEALTH NETWORK |
发明人 |
MEDIN JEFFREY A.;DEVINE SEAN |
分类号 |
A61K35/12;A61K31/7052;A61K35/76;A61P3/00;A61P35/00;C12N5/00;C12N7/00;C12N9/12;C12N15/54;C12N15/63;C12N15/85 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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