METHODS AND COMPOSITIONS FOR THE TREATMENT OF OSTEOARTICULAR DISEASE

摘要

The present invention provides methods, and compositions for prophylactic and therapeutic treatment of a mammal (e.g. a human) suffering from an osteoarticular disease, such as osteoarthritis. More specifically, the present invention relates to the use of MAPK signalling pathway modulators, such as ERK 1/2 inhibitors, CFBA1 inhibitors and p38 activators, to modulate the pathological interactions that occur between subchondral bone cells and cartilage cells during the development and/or progression of osteoarticular diseases. Suitably, modulation of these interactions at least partly alleviates major symptoms associated with osteoarticular diseases and slows disease progression, thereby reducing the need for surgical intervention and anti-inflammatory medication.