发明名称 |
REPLICATION-COMPETENT ANTI-CANCER VECTORS |
摘要 |
Novel vectors which are replication-competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and methods for promoting the death of neoplastic cells using these replication-competent vectors are also disclosed.
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申请公布号 |
CA2378586(C) |
申请公布日期 |
2011.05.03 |
申请号 |
CA20002378586 |
申请日期 |
2000.07.12 |
申请人 |
ST. LOUIS UNIVERSITY |
发明人 |
WOLD, WILLIAM S. M.;TOTH, KAROLY;DORONIN, KONSTANTIN;TOLLEFSON, ANN E. |
分类号 |
C12N15/09;C12N15/86;A61K31/711;A61K35/76;A61K45/00;A61K48/00;A61P31/12;A61P35/00;A61P43/00;C07K14/075;C12N5/10;C12N7/00;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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