PROTEINS, NUCLEIC ACIDS AND MEDICAMENTS

摘要

The invention provides TGF-ss3s, or fragments or derivatives thereof, wherein the alpha-helix-forming domain between amino acids residues 58 and 67 of full-length wild type TGF-ss3 comprises at least one alpha-helix-stabilising substitution. The invention also provides TGF-ss3s, or fragments or derivatives thereof, wherein the Glycine residue at position 63 of full- length wild type TGF-ss is replaced with Proline. Further still, the invention provides TGF-ss3s, or fragments or derivatives thereof, comprising a substitution of the Glutamic acid residue at position 12 of full-length wild type TGF-ss3 and/or the Arginine residue at position 52 of full-length wild type TGF-ss3. The invention also provides medicaments and methods of treatment using such TGF-ss3s.