发明名称 Nitrosated Nonsteroidal Antiinflammatory Compounds, Compositions and Methods of Use
摘要 The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders comprising administration of novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent.
申请公布号 US2011098253(A1) 申请公布日期 2011.04.28
申请号 US20100980077 申请日期 2010.12.28
申请人 NICOX S.A. 发明人 EARL RICHARD;EZAWA MAIKO;FANG XINQUIN;GARVEY DAVID S.;GASTON RICKY D.;KHANAPURE SUBHASH P.;LETTS L. GORDON;LIN CHIA-EN;RANATUNGE RAMANI R.;RICHARDSON STEWART K.;SCHROEDER JOSEPH D.;STEVENSON CHERI A.;WEY SHIOW-JYI
分类号 A61K31/216;C07D295/08;A61K31/21;A61K31/27;A61K31/34;A61K31/357;A61K31/401;A61K31/405;A61K31/445;A61K31/495;A61K31/56;A61K31/662;A61K45/00;A61P1/00;A61P1/04;A61P1/10;A61P1/14;A61P3/04;A61P9/00;A61P11/06;A61P17/02;A61P19/02;A61P25/28;A61P27/02;A61P29/00;A61P31/04;A61P35/00;A61P35/02;A61P43/00;C07C203/04;C07C205/40;C07C205/56;C07C219/10;C07C229/42;C07C235/08;C07C235/12;C07C235/34;C07C235/42;C07C237/08;C07C243/28;C07C271/16;C07C271/64;C07C291/02;C07C311/17;C07C317/18;C07C317/32;C07C317/46;C07C323/12;C07C327/28;C07D209/18;C07D209/28;C07D211/22;C07D211/56;C07D493/04;C07F9/40 主分类号 A61K31/216
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