Methods for treating neurodegeneration and/or myelination in patients are disclosed comprising treating the patient with a progestin compound which exerts binding to progesterone receptors and elicits progesterone-receptor-induced biological responses without interacting with the androgen receptor and without inducing androgen or glucocorticoid biological responses at a dosage sufficient to prevent or reduce neurodegeneration. The progestin compound preferably comprises 16-methylene-17a-acetoxy-19-norpregn-4-ene-3, 20-dione, and the methods include combining the progestin compound with an estrogen compound to provide both contraception and treatment for myelin repair and neurodegeneration.
申请公布号
CA2777551(A1)
申请公布日期
2011.04.28
申请号
CA20102777551
申请日期
2010.10.19
申请人
THE POPULATION COUNCIL, INC.
发明人
SITRUK-WARE, REGINE;SCHUMACHER, MICHAEL MARIA HELMUT;BRINTON, ROBERTA;EL-ETR, MARTINE;GHOUMARI, ABDELMOUMAN;GUENNOUN, RACHIDA