| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for simply and efficiently producing 2'-O-silylated ribonucleoside without using an expensive protecting group and a specific raw material. <P>SOLUTION: The method for producing a silylated RNA, its salt or their mixture includes reacting an RNA containing two or more ribonucleotides, its salt or their mixture with a silylating agent to give a silylated RNA containing 2'-O-silylated ribonucleotide, its salt or their mixture. The method for producing a silylated ribonucleoside, a phosphate derivative of a silylated ribonucleoside, its salt or their mixture includes decomposing a silylated RNA containing 2'-O-silylated ribonucleotide, its salt or their mixture by a hydrolysis reaction to give a silylated ribonucleoside, a phosphate derivative of a silylated ribonucleoside, its salt or their mixture. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
