发明名称 |
PROXIMITY-MEDIATED ASSAYS FOR DETECTING ONCOGENIC FUSION PROTEINS |
摘要 |
The present invention provides antibody-based arrays for detecting the activation state and/or total amount of one or a plurality of oncogenic fusion proteins in a biological sample such as whole blood or tumor tissue and methods of use thereof. In certain instances, the activation state and/or total amount of oncogenic fusion protein(s) present in a sample can be measured in combination with one or a plurality of signal transduction molecules. The compositions and methods of the present invention have the advantages of specificity associated with enzyme-linked immunosorbent assays, sensitivity associated with signal amplification, and high-throughput multiplexing associated with microarrays.
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申请公布号 |
CA2777934(A1) |
申请公布日期 |
2011.04.28 |
申请号 |
CA20102777934 |
申请日期 |
2010.10.20 |
申请人 |
PROMETHEUS LABORATORIES INC. |
发明人 |
SINGH, SHARAT;LIU, XINJUN |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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