SENESCENE CELLS AND METHODS FOR ITS PRODUCTION

摘要

The present invention relates to a method for the generation of transduced cell lines susceptible to senescence whereby the senescence is exogenously inducible. In particular, the present invention relates to a method for the generation of transduced cell lines susceptible to senescence wherein two or more different immortalizing gene sequences have been incorporated whereby said immortalizing gene sequences are regulated by regulators controlled via exogenous means. In a further aspect, the present invention relates to transduced cell lines obtainable with said method. In addition, methods for screening molecules influencing senescence of cells are provided as well as kits for conducting the same.