TEMPORALLY PATTERNED OVEREXPRESSION OF Foxg1 AND Emx2 TRANSCRIPTION FACTOR GENES IN NEURAL PRECURSORS FOR BRAIN TISSUE REPAIR

摘要

The present invention relates to a recombinant expression vector suitable for gene therapy and able to effectively express in a differentially state specific manner Emx2 and/or Foxg polypeptides or functional fragments thereof in neural stem cells (NSCs) and/or in neuron- restricted progenitors (NPs)as well as a neural stem cell (NSCs), or a neuron-restricted progenitor (NPs) cell or a mixed cell population thereof transformed with such10 recombinant expression vector.