发明名称 |
USING INHIBITORS OF HISTONE DEACETYLASES FOR THE SUPPRESSION THERAPY OF INHERITED DISEASE PREDISPOSING CONDITIONS |
摘要 |
Compounds can be used to act as inhibitors of enzymes having histone deacetylase activity for the medical therapy of conditions which predispose a person for the development of a disease, such as but not limited to cancer, inflammatory or metabolic diseases. Such conditions are linked to genetically inherited mutations of crucial genes which predispose a person with this condition to develop the disease phenotype. Thus, such compounds can be used for a suppressive therapeutic approach—the SUPPRESSION THERAPY—in order to inhibit or delay the onset or progression of the genetically predisposed disorder. Furthermore, a clinically used medicament can be manufactured for the SUPPRESSION THERAPY of such inherited predisposing conditions.
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申请公布号 |
US2011092447(A1) |
申请公布日期 |
2011.04.21 |
申请号 |
US20100975802 |
申请日期 |
2010.12.22 |
申请人 |
HENTSCH BERND;MAURER ALEXANDER B;HOVELMANN SASCHA;RAAB MONIKA;MARTIN ELKE |
发明人 |
HENTSCH BERND;MAURER ALEXANDER B.;HOVELMANN SASCHA;RAAB MONIKA;MARTIN ELKE |
分类号 |
A61K31/19;A61K31/16;A61K31/167;A61K31/185;A61K31/20;A61K31/22;A61K31/225;A61K31/336;A61K31/404;A61K31/4353;A61K31/4406;A61K31/4436;A61K31/473;A61K31/505;A61K38/12;A61P3/10;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P19/08;A61P25/00;A61P29/00;A61P35/00;A61P37/02 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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