COATINGS COMPRISING BIS-(ALPHA-AMINO-DIOL-DIESTER) CONTAINING POLYESTERAMIDE

摘要

The present invention relates to a coating comprising at least one biodegradable polymer, wherein the polymer comprises at least one or a blend of a poly (ester amide) (PEA) having a chemical formula described by structural formula (II), wherein; R1 is independently selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, -(R9-CO-O-R10-O-CO-R9)-, CH R11-O-CO-R12-COOCR11- and combinations thereof; R3 and R4 in a single co-monomer m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C1C6)alkyl, -(CH2)SH, - (CH2)2S(CH 3), CH2OH, -CH(OH)CH3, -(CH2)4NH3+, ~(CH2)3NHC(=NH2+)NH2, -CH2COOH, (CH2)COOH, -CH2-CO-NH2 -CH2CH2-CO-NH2, - -CH2CH2COOH, CH3-CH2-CH(CH3)-, formula (a), HO-P-Ph-CH2-, (CH3)2-CH-, Ph-NH-, NH-(CH2)3-C-, NH-CH=N-CH=C-CH2-. R5 or R6 are independently selected from bicyclic-fragments of 1,4:3,6- dianhydrohexitols or from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy, oligoethyleneglycol with a Mw ranging from 44 Da up to 700 Da, -CH2-CH-(CH2OH)2, CH2CH(OH)CH2 whereby R5 and R6 are non identical. R7 is hydrogen, (C6-C10) aryl, (C1C6) alkyl or a protecting group such as benzyl- or a bioactive agent; R8 is independently (C1-C20) alkyl or (C2-C20)alkenyl; R9 or R10 are independently selected from C2-C12 alkylene or C2-C12 alkenylene and R11 or R12 are independently selected from H, methyl, C2-C12 alkylene or C2-C12 alkenylene.