发明名称 |
VACCINE STRAIN OF B/60/MALAYSIA/04/898 INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN |
摘要 |
FIELD: medicine. ^ SUBSTANCE: B/60/Malaysia/04/898 strain actively replicates in growing chicken embryos at optimum temperature 32-33C. It is characterised by thermal sensitivity and cold adaptation. A reassortant has inherited the genes coding surface virus antigens - hemagglutinin (HA) and neuraminidase (NA) from an epidemic parent virus. The other six genes code internal non-glycosylated proteins from an attenuation donor. The B/60/Malaysia/04/898 strain is areactogenic for adults and children in intranasal introduction. ^ EFFECT: invention can be used in practical health services for preventing seasonal influenza incidence in adults and children by a live influenza intranasal vaccine of the strain of said influenza virus. ^ 4 tbl |
申请公布号 |
RU2416639(C1) |
申请公布日期 |
2011.04.20 |
申请号 |
RU20090149606 |
申请日期 |
2009.12.30 |
申请人 |
UCHREZHDENIE ROSSIJSKOJ AKADEMII MEDITSINSKIKH NAUK NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT EHKSPERIMENTAL'NOJ MEDITSINY SEVERO-ZAPADNOGO OTDELENIJA RAMN (NIIEHM SZO RAMN) |
发明人 |
LARIONOVA NATAL'JA VALENTINOVNA;KISELEVA IRINA VASIL'EVNA;RUDENKO LARISA GEORGIEVNA;ALEKSANDROVA GALINA IBRAGIMOVNA |
分类号 |
A61K39/145;C12N7/00 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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