发明名称 |
LINGO BINDENDE MOLEKÜLE UND PHARMAZEUTISCHE VERWENDUNG DAVON |
摘要 |
The present invention provides an antibody which is capable of binding to the rat, cynomolgus monkey and human LINGO polypeptide with a dissociation constant <1000nM such that the association of LINGO-1 with NgR is inhibited and neurite outgrowth inhibitory activity of adult rat spinal cord myelin attenuated at sub-nM concentrations. Further provided is the use of such antibody in the treatment of a CNS injury, and a pharmaceutical composition comprising the antibody. |
申请公布号 |
AT502960(T) |
申请公布日期 |
2011.04.15 |
申请号 |
AT20070846601T |
申请日期 |
2007.11.15 |
申请人 |
NOVARTIS AG |
发明人 |
WALMSLEY, ADRIAN ROBERT;WISHART, WILLIAM LEONARD;CORTES-CROS, MARTA;PRASSLER, JOSEF;KLAGGE, INGO |
分类号 |
C07K16/28;A61K39/395 |
主分类号 |
C07K16/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|