摘要 |
The present invention relates to process for preparation of optical resolution of substituted 2-(2-pyridinylmethylsulphinyl)-1H-benzimidazoles either as a single enantiomer or in an enantiomerically enriched form. Thus, for example, R-1,1'-binaphtyl- 2-2'-diyl hydrogen phosphate was reacted with 2-[[[3-methyl-4-(2,2,2-trifluoro-ethoxy)- 2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (Lansoprazole) in a mixture of benzene and cyclohexane to obtain diasteremeric complexes. The diasteremeric complexes were subjected to fractional crystallization to obtain R-2-[[[3-methyl-4-(2,2,2-trifluoro- ethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole.R-1,1'-binaphthyl-2-2'-diyl hydrogen phosphate. The separated isomer was treated with sodium bicarbonate in a mixture of ethyl acetate and water to obtain R-2-[[[3-methyl-4-(2,2,2-trifluoro-ethoxy)-2- pyridinyl]methyl]sulfinyl]-1H-benzimidazole (dexlansoprazole). |
申请人 |
HETERO RESEARCH FOUNDATION;PARTHASARADHI REDDY, BANDI;RATHNAKAR REDDY, KURA;RAJI REDDY, RAPOLU;MURALIDHARA REDDY, DASARI;VAMSI KRISHNA, BANDI;SATYA SRINIVAS, AYYALASOMAYAJULA |
发明人 |
PARTHASARADHI REDDY, BANDI;RATHNAKAR REDDY, KURA;RAJI REDDY, RAPOLU;MURALIDHARA REDDY, DASARI;VAMSI KRISHNA, BANDI;SATYA SRINIVAS, AYYALASOMAYAJULA |