发明名称 |
INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY |
摘要 |
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced. |
申请公布号 |
WO2009126705(A8) |
申请公布日期 |
2011.04.14 |
申请号 |
WO2009US39899 |
申请日期 |
2009.04.08 |
申请人 |
VIRGINIA COMMONWEALTH UNIVERSITY;LEE, RUEY-MIN;LIN, PECK-SUN |
发明人 |
LEE, RUEY-MIN;LIN, PECK-SUN |
分类号 |
A61K31/167;A61K31/53;A61K39/395;A61P35/00 |
主分类号 |
A61K31/167 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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