SIRNA DELIVERY SYSTEM USING SELF-ASSEMBLED POLYMERIC NANOPARTICLES

摘要

The present invention relates to an siRNA delivery system formed of siRNA coupled with amphiphilic polymeric nanoparticles that are composite particles of hydrophilic and hydrophobic polymers, and its use. More specifically, the present invention relates to an siRNA delivery system prepared by coupling amphiphilic polymeric nanoparticles with siRNA (small interfering RNA), the amphiphilic polymeric nanoparticles being composed of self-assembled chitosan-bile acid conjugates and polyethyleneimine (PEI)-bile acid conjugates, and its use. Since the siRNA delivery system of the present invention can efficiently deliver a therapeutic siRNA for prevention of the expression of disease cell-specific proteins in vivo, it can be utilized in a broad range of applications for treating all kinds of diseases.