发明名称 |
Bridged monobactams useful as beta-lactamase inhibitors |
摘要 |
Compounds of the formula II:
in which R8 is of the formula Q-(X) r -CO- wherein either a) X = - CH 2 -, r = 1, Q is a pyridinium group and R7 is -SO 3 - or -OSO 3 - ; or b) X = -SCH 2 - and r = 1; wherein Q is e.g. 1,2,3,4-tetrazol-5-yl and R7 is -SO 3 H or -OSO 3 H; or c) X = -CH 2 NH 2 -, r = 1 and Q is e.g.
phenyl or a 5-6-membered heterocycle and R7 is -SO 3 H or -OSO 3 H; or d) X = -NH 2 - and r = 1, wherein Q is e.g. phenyl and R7 is - SO 3 H or -OSO 3 H; are beta-lactamase inhibitors. They may be used in combination with monobactams against gram-negative bacteria. |
申请公布号 |
EP2308874(A1) |
申请公布日期 |
2011.04.13 |
申请号 |
EP20100167498 |
申请日期 |
2006.12.07 |
申请人 |
BASILEA PHARMACEUTICA AG |
发明人 |
DESARBRE, ERIC;GAUCHER, BERANGERE;PAGE, MALCOLM, G.P.;ROUSSEL, PATRICK |
分类号 |
C07D417/14;A61K31/4427;A61P31/04 |
主分类号 |
C07D417/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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