摘要 |
<p>The present invention comprises glucosylceramide synthase (GCS) inhibitors of structural formula (I), and pharmaceutically acceptable salts thereof, wherein R1, E, A, L, X1, Q, R4, R5, m and n, are as defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprises composition comprising the compounds, N-oxides, and/or pharmaceutically acceptable salts thereof. The invention also comprises use of the compounds and compositions for treating diseases in which GCS is a mediator or is implicated. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases in which GCS is a mediator or is implicated.</p> |
申请人 |
EXELIXIS, INC.;CHAN, WAI, KI, VICKY;DU, HONGWANG;KEARNEY, PATRICK;KOLTUN, ELENA, S.;NACHTIGALL, JASON, AUGUST;NOSON, KEVIN;PACK, MICHAEL;RICHARDS, STEVEN, JAMES |
发明人 |
CHAN, WAI, KI, VICKY;DU, HONGWANG;KEARNEY, PATRICK;KOLTUN, ELENA, S.;NACHTIGALL, JASON, AUGUST;NOSON, KEVIN;PACK, MICHAEL;RICHARDS, STEVEN, JAMES |