NEW MAYTANSINOIDS AND THE USE OF SAID MAYTANSINOIDS TO PREPARE CONJUGATES WITH AN ANTIBODY

摘要

The invention relates to a compound of formula (I): wherein : ° ALK is a (C1-C6)alkylene group; ° X1 et X2 are each independently one of the following groups : -CH=CH-, -CO-, -CONR-, - NRCO-. -COO-. -OCO-. -OCONR-. -NRCOO-. -NRCONR'-. -NR-. -S(O)n (n=0,1 or 2) or O-; ° R and R' are independently H or a (C1-C6)alkyl group; ° I is an integer of from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10; ° j is an integer corresponding to 1 when X2 is -CH=CH- and 2 when X2 is not -CH=CH-; ° Zb is a simple bond, -O- or -NH- and Rb is H or a (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, heteroaryl or (C3-C7)heterocycloalkyl group; or Zb is a single bond and Rb is Hal. The invention relates to the use of said maytansinoids to prepare conjugates with an antibody having an affinity for tumor cells.