发明名称 |
Assessment of skeletal growth using measurements of NT-CNP peptides |
摘要 |
A means of measuring and monitoring skeletal growth rate using a plasma analyte, amino-terminal C-type natriuretic peptide (NT-CNP). Plasma NT-CNP concentrations reflect the potential for further growth of the immature skeleton. Measurement of plasma NT-CNP in a subject, when related to the mean of an appropriate age and gender matched set of control subjects, provides an index of the severity of a growth disorder not otherwise available and facilitates diagnosis in children with undetected osteo-chondrodysplasias or other intrinsic disorders of the growth plate. The invention also provides a means of detecting and monitoring potentially harmful effects of drugs and other factors on skeletal growth long before they are evident using current methods in clinical practice.
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申请公布号 |
US7919255(B2) |
申请公布日期 |
2011.04.05 |
申请号 |
US20040561119 |
申请日期 |
2004.06.17 |
申请人 |
OTAGO INNOVATION LIMITED |
发明人 |
PRICKETT TIMOTHY CHARLES RAMSEY;ESPINER ERIC ARNOLD;RICHARDS ARTHUR MARK;YANDLE TIMOTHY GRANT;NICHOLLS MICHAEL GARY |
分类号 |
G01N33/53;A61P19/00;C07K16/22;C07K16/26;C12N5/20;G01N33/543;G01N33/563;G01N33/577;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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