| 摘要 |
<p>The present invention relates to compounds of the general formula (I) (I) wherein X, n and R<sup>1</sup> are as described herein, as well as pharmaceutically acceptable salts and esters thereof, as well as their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are dual modulators of the serotonin 5-HT<sub>2a</sub> and dopamine D<sub>3</sub> receptors, useful in the treatment and/or the prevention of cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and psychoses comprising paranoia and delusions.</p> |
