PH-SENSITIVE GRAFT COPOLYMER, MANUFACTURING METHOD FOR SAME, AND POLYMER MICELLES USING METHOD

摘要

The present invention relates to a manufacturing method for pH-sensitive graft polymer micelles and a polymer micelle-type pharmaceutical composition containing the graft copolymer, wherein the pH-sensitive graft copolymer micelles are usable as various markers and contrast agents for various molecular images for the diagnosis and treatment of diseases and a carrier for delivery of various medicines according to disease. More specifically, a pH-sensitive graft copolymer forming micelles capable of target-oriented diagnosis and medicine release according to changes in the pH of a body, a manufacturing method thereof and a polymer micelle using the same are provided by inducing a graft copolymer of poly (ß- amino ester) compounds which has a solubility in water depending on pH but is incapable of forming the micelles due to a self-assembly phenomenon, and hydrophilic polyethylene glycol compounds.