A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. <IMAGE>
申请公布号
DE69943205(D1)
申请公布日期
2011.03.31
申请号
DE1999643205
申请日期
1999.08.02
申请人
MOUNTAIN VIEW PHARMACEUTICALS INC.;DUKE UNIVERSITY
发明人
WILLIAMS, DAVID, L.;HERSHFIELD, MICHAEL S.;KELLY, SUSAN J.;SAIFER, MARK G. P.;SHERMAN, MERRY R.