Stable nanoparticle formulations smaller than 1000 nm without the use of any surface modifier or stabilizzer absorbed onto the surface of the particles

摘要

Disclosed is a nanoparticle pharmaceutical formulation comprising a poorly soluble drug substance having an average particle size of less than about 1000 nm, a solid or semisolid dispersion vehicle, and optionally a non-surface modifying excipient and without have a surface modifier or stabilizer absorbed onto the surface of the drug particles. Further disclosed are uses of said formulations and preparation processes thereof.